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已发表论文
对完全切除胸腺癌患者的治疗和生存分析
Authors Mao Y, Wu S
Received 23 April 2015
Accepted for publication 21 July 2015
Published 9 September 2015 Volume 2015:8 Pages 2503—2507
DOI http://dx.doi.org/10.2147/OTT.S87222
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Manfred Beleut
Peer reviewer comments 6
Editor who approved publication: Professor Daniele Santini
Purpose: To investigate the impact of chemotherapy and/or radiotherapy on disease-free survival (DFS) and overall survival (OS) rates of patients with thymic carcinoma after complete resection.
Methods: Between 2001 and 2013, 54 patients with complete resection of thymic carcinoma in Hangzhou Cancer Hospital were retrospectively reviewed. The Kaplan–Meier method was used to evaluate the survival rates. The Cox proportional hazard model was used for multivariate analysis.
Results: Among the 54 patients, Masaoka stage I was observed in seven patients, II in 22 patients, and III in 25 patients. Sixteen patients received adjuvant chemotherapy (six with chemotherapy alone and ten with radiotherapy and chemotherapy), 25 patients received adjuvant radiotherapy, and 13 patients did not receive radiotherapy and/or chemotherapy. The 5-year DFS and OS rates for all patients were 63.0% and 73.4%, respectively. Univariate analysis revealed that radiotherapy was significantly associated with DFS and OS (P =0.014 and P =0.029, respectively), while adjuvant chemotherapy was not (P =0.122 and P =0.373, respectively). Multivariate analysis showed that adjuvant radiotherapy increased DFS (P =0.041), but not OS (P =0.051).
Conclusion: Complete resection followed by adjuvant radiotherapy increased disease-free rates of thymic carcinoma patients.
Keywords: thymic carcinoma, complete resection, adjuvant treatment, radiotherapy, chemotherapy, overall survival
Methods: Between 2001 and 2013, 54 patients with complete resection of thymic carcinoma in Hangzhou Cancer Hospital were retrospectively reviewed. The Kaplan–Meier method was used to evaluate the survival rates. The Cox proportional hazard model was used for multivariate analysis.
Results: Among the 54 patients, Masaoka stage I was observed in seven patients, II in 22 patients, and III in 25 patients. Sixteen patients received adjuvant chemotherapy (six with chemotherapy alone and ten with radiotherapy and chemotherapy), 25 patients received adjuvant radiotherapy, and 13 patients did not receive radiotherapy and/or chemotherapy. The 5-year DFS and OS rates for all patients were 63.0% and 73.4%, respectively. Univariate analysis revealed that radiotherapy was significantly associated with DFS and OS (P =0.014 and P =0.029, respectively), while adjuvant chemotherapy was not (P =0.122 and P =0.373, respectively). Multivariate analysis showed that adjuvant radiotherapy increased DFS (P =0.041), but not OS (P =0.051).
Conclusion: Complete resection followed by adjuvant radiotherapy increased disease-free rates of thymic carcinoma patients.
Keywords: thymic carcinoma, complete resection, adjuvant treatment, radiotherapy, chemotherapy, overall survival
