视频

Automated oxygen control with O2matic® during admission with exacerbation of COPD

 

Authors Hansen EF, Hove JD, Sandau Bech C, Stæhr Jensen JU, Kallemose T, Vestbo J

Received 15 August 2018

Accepted for publication 7 November 2018

Published 14 December 2018 Volume 2018:13 Pages 3997—4003

DOI https://doi.org/10.2147/COPD.S183762

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell

Purpose: It is a challenge to control oxygen saturation (SpO2) in patients with exacerbations of COPD during admission. We tested a newly developed closed-loop system, O2matic®, and its ability to keep SpO2 within a specified interval compared with manual control by nursing staff.
Patients and methods: We conducted a crossover trial with patients admitted with an exacerbation of COPD and hypoxemia (SpO
2 ≤88% on room air). Patients were monitored with continuous measurement of SpO2. In random order, they had 4 hours with manually controlled oxygen and 4 hours with oxygen delivery controlled by O2matic. Primary outcome was time within a prespecified SpO2 target interval. Secondary outcomes were time with SpO2 <85%, time with SpO2 below target but not <85%, and time with SpO2 above target.
Results: Twenty patients were randomized and 19 completed the study. Mean age was 72.4 years and mean FEV
1 was 0.72 L (33% of predicted). Patients with O2matic-controlled treatment were within the SpO2 target interval in 85.1% of the time vs 46.6% with manually controlled treatment (<0.001). Time with SpO2 <85% was 1.3% with O2matic and 17.9% with manual control (=0.01). Time with SpO2 below target but not <85% was 9.0% with O2matic and 25.0% with manual control (=0.002). Time with SpO2 above target was not significantly different between treatments (4.6% vs 10.5%, =0.2). Patients expressed high confidence and a sense of safety with automatic oxygen delivery.
Conclusion:
 O2matic was able to effectively control SpO
2 for patients admitted with an exacerbation of COPD. O2matic was significantly better than manual control to maintain SpO2 within target interval and to reduce time with unintended hypoxemia.
Keywords: oxygen therapy, oxygen saturation, hypoxia, hyperoxia, closed-loop


 

摘要视频链接:Automated oxygen control with O2matic®