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智能刺激响应和线粒体靶向药物递送系统在癌症治疗中的应用
Authors Huang Y, Wang T, Tan Q, He D, Wu M, Fan J, Yang J, Zhong C, Li K, Zhang J
Received 12 April 2021
Accepted for publication 22 May 2021
Published 15 June 2021 Volume 2021:16 Pages 4117—4146
DOI https://doi.org/10.2147/IJN.S315368
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Israel (Rudi) Rubinstein
摘要：线粒体 (Mc) 功能与肿瘤的发生发展密切相关。如何将治疗剂特异性地递送到线粒体并发挥精准治疗作用是一项重大挑战。智能药物递送系统主要基于刺激响应性 (St) 和主动靶向性。在这里，我们系统性地综述了智能刺激响应和线粒体靶向药物递送系统（St-Mc-DDS）的设计原理、智能特性、抗癌机制、剂型特点、临床研究进展等。与传统的药物递送系统相比，St-Mc-DDS 表现出更高的疗效和安全性。此外，我们还对 St-Mc-DDS 面临的挑战和未来前景作了全面的阐述。本篇综述是就刺激响应和线粒体靶向药物递送系统的首次全面报道，希望能为智能药物递送系统的研究和应用提供参考。
关键词：智能递送；刺激响应性；线粒体靶向；肿瘤微环境；癌症
