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新型聚乙烯醇纳米粒的靶向抗菌作用及对耐甲氧西林金黄色葡萄球菌感染后皮肤创面愈合的促进作用

 

Authors Wu D, Wei D, Du M, Ming S, Ding Q, Tan R

Received 24 January 2021

Accepted for publication 28 April 2021

Published 10 June 2021 Volume 2021:16 Pages 4031—4044

DOI https://doi.org/10.2147/IJN.S303529

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Yan Shen

Introduction: Topical agents typically remain in the wound site for time duration that are too short to effectively eradicate MRSA tradition formation of BZK that can be maintained within the wound site for longer time periods, should be more effective.
Methods: The novel chitosan and poly (D,L-lactide-co-glycoside) nanoparticles loaded with benzalkonium bromide (BZK) were designed, for the promotion wound healing after MRSA infection. The physical characterization of these nanoparticles, as well as their antibacterial activity in vitro, release profile in simulated wound fluid, cell toxicity, anti-biofilm activity, and their ability to improve the skin wound healing in a mouse model were also studied.
Results: These novel nanoparticles were found to have a significant antibacterial activity (p< 0.01), both in vitro and in vivo test. The stronger anti-biofilm ability of the nanoparticles to inhibit the formation of bacterial biofilms, at a concentration of 3.33 μg/mL, and clear existing bacterial biofilms, at a concentration of 5 mg/mL, compared with its water solution. In addition, significant damage to bacterial cell walls also was found, providing insight into the mechanism of antibacterial activity.
Conclusion: Taken together, these results demonstrated the ability of BZK-loaded nanoparticles in the promotion of skin wound healing with MRSA infection. The current findings open a new avenue for nanomedicine development and future clinical applications in the treatment of wounds.
Keywords: MRSA, wound, nanoparticles, antibacterial effect, biofilm