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Authors Stavraka C, Rush H, Ross P
Received 4 September 2018
Accepted for publication 8 November 2018
Published 28 December 2018 Volume 2019:6 Pages 11—21
DOI https://doi.org/10.2147/JHC.S159805
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Professor Ahmed O Kaseb
Abstract: Combined
hepatocellular cholangiocarcinoma (CC) is a rare and aggressive primary hepatic
malignancy with significant histological and biological heterogeneity. It
presents with more aggressive behavior and worse survival outcomes than either
hepatocellular carcinoma or CC and remains a diagnostic challenge. An accurate
diagnosis is crucial for its optimal management. Major hepatectomy with hilar
node resection remains the mainstay of treatment in operable cases. Advances in
the genetic and molecular characterization of this tumor will contribute to the
better understanding of its pathogenesis and shape its future management.
Keywords: cholangiocarcinoma,
hepatocellular carcinoma, combined, genetics, molecular biology, treatment,
mixed liver tumors, primary liver cancer