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以结节性红斑为首发表现的免疫介导坏死性肌病
Authors Ying S, Li S, Tang S, Sun Q, Fang D, Li Y, Zhu D, Fang H, Qiao J
Received 17 July 2020
Accepted for publication 11 August 2020
Published 24 August 2020 Volume 2020:13 Pages 471—476
DOI https://doi.org/10.2147/JIR.S270114
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Ning Quan
摘要：免疫介导的坏死性肌病 (IMNM) 是一种自身免疫性肌病，特征表现为出现严重的弥漫性近端肌纤维坏死的炎症性肌病。IMNM 有两种特殊的自身抗体，分别为 SRP 抗体及 HMGCR 抗体。结节性红斑常伴发于多种系统性疾病，如自身炎症性疾病。我们报道一例 SRP 抗体阳性的免疫介导坏死性肌病的病例，结节性红斑为该患者的首发临床表现。在使用糖皮质激素，静脉注射免疫球蛋白，利妥昔单抗和马替麦考酚酯治疗后，这位患者获得了明显的临床改善。本病例报道表明IMNM最初可以结节性红斑的形式出现，两者的发病机制可能有重叠。
Keywords: immune-mediated necrotizing myopathy, erythema nodosum, autoantibody
